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Would Carnosine or a Carnivorous Diet Help Suppress Aging and Associated Pathologies?

URL: https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1196/annals.1354.052

Journal: Annals of the New York Academy of Sciences

 Publication Date: 05/2006

 Summary: Carnosine has the potential to suppress many of the biochemical changes (e.g., protein oxidation, glycation, AGE formation, and cross‐linking) that accompany aging and associated pathologies. Glycation, generation of advanced glycosylation end‐products (AGEs), and formation of protein carbonyl groups play important roles in aging, diabetes, its secondary complications, and neurodegenerative conditions. It is suggested that carnivorous diets could be beneficial because of their carnosine content, as the dipeptide has been shown to suppress some diabetic complications in mice. It is also suggested that carnosine’s therapeutic potential should be explored with respect to neurodegeneration.