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Glycation, ageing and carnosine: Are carnivorous diets beneficial?

URL: https://www.sciencedirect.com/science/article/pii/S0047637405001193

Journal: Mechanisms of Ageing and Development

 Publication Date: 10/2005

 Summary: Non-enzymic protein glycosylation (glycation) plays important roles in ageing and in diabetes and its secondary complications. Dietary constituents may play important roles in accelerating or suppressing glycation. It is suggested that carnivorous diets contain a potential anti-glycating agent, carnosine (β-alanyl-histidine), whilst vegetarians may lack intake of the dipeptide. The possible beneficial effects of carnosine and related structures on protein carbonyl stress, AGE formation, secondary diabetic complications and age-related neuropathology are discussed.

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Would Carnosine or a Carnivorous Diet Help Suppress Aging and Associated Pathologies?

URL: https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1196/annals.1354.052

Journal: Annals of the New York Academy of Sciences

 Publication Date: 05/2006

 Summary: Carnosine has the potential to suppress many of the biochemical changes (e.g., protein oxidation, glycation, AGE formation, and cross‐linking) that accompany aging and associated pathologies. Glycation, generation of advanced glycosylation end‐products (AGEs), and formation of protein carbonyl groups play important roles in aging, diabetes, its secondary complications, and neurodegenerative conditions. It is suggested that carnivorous diets could be beneficial because of their carnosine content, as the dipeptide has been shown to suppress some diabetic complications in mice. It is also suggested that carnosine’s therapeutic potential should be explored with respect to neurodegeneration.

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Efficacy of l-carnitine supplementation for management of blood lipids: A systematic review and dose-response meta-analysis of randomized controlled trials

URL: https://www.sciencedirect.com/science/article/abs/pii/S0939475319302807

Journal: Nutrition, Metabolism and Cardiovascular Diseases

 Publication Date: 07/2019

 Summary: l-carnitine supplementation at doses above 2 g/d has favorable effects on patients’ lipid profiles, but is modulated on participant health and route of administration.

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L-carnitine ameliorated weight loss in fasting therapy: A propensity score-matched study

URL: https://www.sciencedirect.com/science/article/abs/pii/S0965229918312019

Journal: Complementary Therapies in Medicine

 Publication Date: 06/2019

 Summary: Weight and BMI decreased in both groups, but significantly more in l-carnitine group, while diastolic blood pressureand triglycerides decreased significantly more in non-l-carnitine group compared between groups, blood glucose did not differ significantly between groups. l-carnitine can boost the positive effects of fasting therapy on weight loss and maintain the stability of blood pressure.

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The effect of l-carnitine supplementation on lipid profile and glycaemic control in adults with cardiovascular risk factors: A systematic review and meta-analysis of randomized controlled clinical trials

URL: https://www.sciencedirect.com/science/article/pii/S026156141930038X

Journal: Clinical Nutrition

 Publication Date: 02/2019

 Summary: This meta-analysis showed that l-carnitine supplementation could improve lipid profile levels, particularly in doses more than 1500 mg/day. More RCTs with large sample sizes, focusing on gut microbiome profiles and dietary patterns are needed to better understand the effect of l-carnitine on patients with cardiovascular risk factors.

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The Inhibition of Advanced Glycation End Products by Carnosine and Other Natural Dipeptides to Reduce Diabetic and Age‐Related Complications

URL: https://onlinelibrary.wiley.com/doi/full/10.1111/1541-4337.12376

Journal: Comprehensive Reviews in Food Science and Food Safety

 Publication Date: 07/2018

 Summary: Carnosine has been shown to prevent AGE formations through reduction of blood glucose, prevention of early glycation, and even reversing previously formed AGEs.

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L-Carnitine supplementation reduces the general fatigue of cancer patients during chemotherapy

URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795559/

Journal: Molecular and Clinical Oncology

 Publication Date: 03/2018

Summary: LC-Carnitine supplementation improved general fatigue in all the examined cancer patients during chemotherapy. This treatment may improve the tolerability of chemotherapy in cancer patients by reducing general fatigue and improving the nutritional status.

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Acetyl-L-Carnitine Supplementation and the Treatment of Depressive Symptoms: A Systematic Review and Meta-Analysis

URL: https://www.ncbi.nlm.nih.gov/m/pubmed/29076953/

Journal: Psychosomatic Medicine

Publication Date: 02/2018

 Summary: Acetyl l-carnitine supplementation significantly decreases depressive symptoms compared with placebo/no intervention, while offering a comparable effect with that of established antidepressant agents with fewer adverse effects.

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l-Carnitine and heart disease

URL: https://www.ncbi.nlm.nih.gov/m/pubmed/29241711/

Journal: Life Science

 Publication Date: 02/2018

Summary: Exogenous carnitine administration through dietary and intravenous routes serves as a suitable protective strategy against ventricular dysfunction, ischemia-reperfusion injury, cardiac arrhythmia and toxic myocardial injury that prominently mark CVD. Additionally, carnitine reduces hypertension, hyperlipidemia, diabetic ketoacidosis, hyperglycemia, insulin-dependent diabetes mellitus, insulin resistance, obesity, etc. that enhance cardiovascular pathology. These favorable effects of l-carnitine have been evident in infants, juvenile, young, adult and aged patients of sudden and chronic heart failure as well.