Journal: Mechanisms of Ageing and Development
Publication Date: 10/2005
Summary: Non-enzymic protein glycosylation (glycation) plays important roles in ageing and in diabetes and its secondary complications. Dietary constituents may play important roles in accelerating or suppressing glycation. It is suggested that carnivorous diets contain a potential anti-glycating agent, carnosine (β-alanyl-histidine), whilst vegetarians may lack intake of the dipeptide. The possible beneficial effects of carnosine and related structures on protein carbonyl stress, AGE formation, secondary diabetic complications and age-related neuropathology are discussed.
Journal: Annals of the New York Academy of Sciences
Publication Date: 05/2006
Summary: Carnosine has the potential to suppress many of the biochemical changes (e.g., protein oxidation, glycation, AGE formation, and cross‐linking) that accompany aging and associated pathologies. Glycation, generation of advanced glycosylation end‐products (AGEs), and formation of protein carbonyl groups play important roles in aging, diabetes, its secondary complications, and neurodegenerative conditions. It is suggested that carnivorous diets could be beneficial because of their carnosine content, as the dipeptide has been shown to suppress some diabetic complications in mice. It is also suggested that carnosine’s therapeutic potential should be explored with respect to neurodegeneration.
Journal: Nutrition, Metabolism and Cardiovascular Diseases
Publication Date: 07/2019
Summary: l-carnitine supplementation at doses above 2 g/d has favorable effects on patients’ lipid profiles, but is modulated on participant health and route of administration.
Journal: Complementary Therapies in Medicine
Publication Date: 06/2019
Summary: Weight and BMI decreased in both groups, but significantly more in l-carnitine group, while diastolic blood pressureand triglycerides decreased significantly more in non-l-carnitine group compared between groups, blood glucose did not differ significantly between groups. l-carnitine can boost the positive effects of fasting therapy on weight loss and maintain the stability of blood pressure.
Journal: Clinical Nutrition
Publication Date: 02/2019
Summary: This meta-analysis showed that l-carnitine supplementation could improve lipid profile levels, particularly in doses more than 1500 mg/day. More RCTs with large sample sizes, focusing on gut microbiome profiles and dietary patterns are needed to better understand the effect of l-carnitine on patients with cardiovascular risk factors.
Journal: Amino Acids
Publication Date: 09/2018
Summary: Carnosine has anti-glycating properties, and may hinder the formation of protein carbonyls and the cross-links induced by reduced sugars; however, there were few human studies.
Journal: Comprehensive Reviews in Food Science and Food Safety
Publication Date: 07/2018
Summary: Carnosine has been shown to prevent AGE formations through reduction of blood glucose, prevention of early glycation, and even reversing previously formed AGEs.
Journal: Molecular and Clinical Oncology
Publication Date: 03/2018
Summary: LC-Carnitine supplementation improved general fatigue in all the examined cancer patients during chemotherapy. This treatment may improve the tolerability of chemotherapy in cancer patients by reducing general fatigue and improving the nutritional status.
Journal: Psychosomatic Medicine
Publication Date: 02/2018
Summary: Acetyl l-carnitine supplementation significantly decreases depressive symptoms compared with placebo/no intervention, while offering a comparable effect with that of established antidepressant agents with fewer adverse effects.
Journal: Life Science
Publication Date: 02/2018
Summary: Exogenous carnitine administration through dietary and intravenous routes serves as a suitable protective strategy against ventricular dysfunction, ischemia-reperfusion injury, cardiac arrhythmia and toxic myocardial injury that prominently mark CVD. Additionally, carnitine reduces hypertension, hyperlipidemia, diabetic ketoacidosis, hyperglycemia, insulin-dependent diabetes mellitus, insulin resistance, obesity, etc. that enhance cardiovascular pathology. These favorable effects of l-carnitine have been evident in infants, juvenile, young, adult and aged patients of sudden and chronic heart failure as well.