Inflammation

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The Effect of Low-Carbohydrate and Low-Fat Diets on Pain in Individuals with Knee Osteoarthritis

URL: https://academic.oup.com/painmedicine/article-abstract/21/1/150/5380130?redirectedFrom=fulltext

Journal: Pain Medicine

Publication Date: 01/2020

Summary: Osteoarthritis is the most prominent form of arthritis, affecting approximately 15% of the population in the United States. Knee osteoarthritis (KOA) has become one of the leading causes of disability in older adults. Besides knee replacement, there are no curative treatments for KOA, so persistent pain is commonly treated with opioids, acetaminophen, and nonsteroidal anti-inflammatory drugs. However, these drugs have many unpleasant side effects, so there is a need for alternative forms of pain management. We sought to test the efficacy of a dietary inter- vention to reduce KOA. A randomized controlled pilot study to test the efficacy of two dietary interventions. Subjects. Adults 65–75 years of age with KOA. Participants were asked to follow one of two dietary interventions (low-carbohydrate [LCD], low-fat [LFD]) or continue to eat as usual (control [CTRL]) over 12 weeks. Functional pain, self-reported pain, quality of life, and depression were assessed every three weeks. Serum from before and af- ter the diet intervention was analyzed for oxidative stress. Over a period of 12 weeks, the LCD reduced pain intensity and unpleasantness in some functional pain tasks, as well as self-reported pain, compared with the LFD and CTRL. The LCD also significantly reduced oxidative stress and the adipokine leptin compared with the LFD and CTRL. Reduction in oxidative stress was related to reduced functional pain. We present evidence suggesting that oxidative stress may be related to functional pain, and lowering it through our LCD intervention could provide relief from pain and be an opioid alternative.

Effects of Total Red Meat Consumption on Glycemic Control and Inflammation: A Systematically Searched Meta-analysis and Meta-regression of Randomized Controlled Trials (OR22-08-19)

URL: https://academic.oup.com/cdn/article/3/Supplement_1/nzz028.OR22-08-19/5516820 Journal: Current Developments in Nutrition  Publication Date: 06/2019  Summary: Consuming ≥ vs <0.5 servings/d of red meat showed greater decreases in insulin when carbohydrates were replaced with red meat but lesser decreases in HOMA-IR when macronutrient distributions were matched between intervention and control eating patterns.

Protein-enriched diet, with the use of lean red meat, combined with progressive resistance training enhances lean tissue mass and muscle strength and reduces circulating IL-6 concentrations in elderly women: a cluster randomized controlled trial

URL: https://academic.oup.com/ajcn/article/99/4/899/4637870 Journal: The American Journal of Clinical Nutrition Publication Date: 04/2014 Summary: 100 elderly women were randomized to a high protein diet supplemented with lean red meat combined with progressive resistance training versus progressive resistance training with a control diet. Lean tissue mass and strenghth increased more in the meat supplemented group. IGF-1 increase more and IL-6 decreased more in the meat supplemented group

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